MMP7 Polymorphisms - A new tool in molecular pathology to understand esophageal cancer
نویسندگان
چکیده
منابع مشابه
MMP7 and MMP8 genetic polymorphisms in bladder cancer patients
INTRODUCTION Breakdown of the extracellular matrix by matrix metalloproteinases (MMPs), as we know, is one of mechanisms involved and required in tumor invasion. MMP7 is a negative prognostic factor of various malignances, while MMP8 exhibits an inhibitory effect on tumorigenesis and metastasis. We evaluated the potential association of functional polymorphisms in the promoter of the MMP7 (rs11...
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Abstract Background: Esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. This may be due to increasing rates of Barrett’s esophagus, gastroesophageal reflux, smoking and obesity. This study was performed from 1991 to 2005 in order to evaluate vario...
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Esophageal cancer (EC) is a global health problem, and an estimated 482, 300 new esophageal cancer cases and 406, 800 deaths occurred in 2008 worldwide (Jemal et al., 2011). Its incidence rates vary internationally, and the highest rates found in Southern and Eastern Africa and Eastern Asia were nearly 16-fold, compared with lowest rates observed in Western and Middle Africa and Central America...
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Objectives: This study aimed to explore the effect of AXIN2 and MMP7 polymorphisms on non-small cell lung cancer (NSCLC) susceptibility; in addition, the interaction between gene polymorphisms and environment was also displayed. Methods: The genotyping was conducted by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 102 patients with NSCLC and 120 healthy contro...
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Background Despite the long history associated with varicocele, it remains one of the most controversial issues in the field of Andrology. The main base of this is our current understanding of the pathophysiology of this disease. This has hampered treatment and management of varicocele, especially regarding why, when and to whom varicocelectomy should be applied. The main molecular pathology of...
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ژورنال
عنوان ژورنال: Saudi Journal of Gastroenterology
سال: 2011
ISSN: 1319-3767
DOI: 10.4103/1319-3767.84479